Peptide Research Guide
Browse all PepGuide research profiles or narrow the directory by topic. Each page separates approved-product evidence, human research, preclinical findings and community reports so the strength of a claim is easier to judge.
Educational research reference only, not medical advice. Evidence strength and regulatory status vary substantially between compounds.
43 research profiles
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5-Amino-1MQ
5-Amino-1MQ is included because peptide clinics and metabolic-stacking discussions often mention it, but chemically it is not a peptide. It is usually discussed as an NNMT inhibitor related to fat-cell metabolism and NAD…
Read profile →Adamax
Adamax is best understood as a modified Semax-family nootropic rather than as an approved medication. The advertised purpose is longer-lasting cognitive and neuroprotective signaling after intranasal use, mainly by…
Read profile →Adipotide
Adipotide is a targeted pro-apoptotic fat-vasculature compound. The animal data are notable, especially the obese-rhesus-monkey study, but the mechanism is tissue injury rather than reversible hormone signaling. Human…
Read profile →AHK-Cu
AHK-Cu is a copper-binding tripeptide used mainly in topical scalp and skin products. It is discussed for hair-follicle signaling and dermal remodeling, not for whole-body hormone effects. Evidence lens: The evidence is…
Read profile →AOD-9604
AOD-9604 is a modified fragment of human growth hormone intended to isolate fat-metabolism signaling without full hGH activity. Evidence lens: It has more human safety context than many gray-market peptides, but that is…
Read profile →ARA-290
ARA-290, also called cibinetide, is engineered from erythropoietin biology but is designed not to increase red blood cell production. Its intended target is the innate repair receptor, which is upregulated during tissue…
Read profile →Bacteriostatic Water
Bacteriostatic water is sterile water containing benzyl alcohol preservative. It is used as a diluent for some multi-dose products, not as a peptide therapy. Evidence lens: Its value is contamination control after vial…
Read profile →BPC-157
BPC-157 is the most widely discussed “repair peptide” in the wellness and biohacking world. The repair story is plausible because the molecule has strong preclinical data in tendon, ligament, muscle, vascular, and…
Read profile →Cagrilintide
Cagrilintide is an amylin analog. In the CagriSema combination, it is paired with semaglutide so that one component strengthens satiety/satiation signaling while the GLP-1 component reduces appetite and improves glycemic…
Read profile →Cerebrolysin
Cerebrolysin is not one peptide. It is a mixture of low-molecular-weight neuropeptides and amino acids derived from porcine brain tissue. That makes it different from a single-sequence synthetic peptide with one…
Read profile →CJC-1295
CJC-1295 is a growth-hormone-releasing hormone analog. The single most important distinction is whether the product has DAC. No-DAC products behave like short GHRH pulses; DAC products bind albumin and last for days.…
Read profile →Dermorphin
Dermorphin is a mu-opioid receptor agonist peptide. It belongs in the guide because it is a peptide, but it should not be grouped mentally with repair, cosmetic, or metabolic peptides. Evidence lens: The safety context…
Read profile →Dihexa
Dihexa is a synthetic angiotensin-IV-derived compound marketed as a cognitive and neurorepair peptide. For a beginner, the key point is that it is not an approved medicine and not a clinically validated nootropic. It is…
Read profile →DSIP / Emideltide
DSIP stands for delta sleep-inducing peptide. The FDA name used in the 2026 compounding review is Emideltide. It is a nine-amino-acid peptide that became famous because early rabbit experiments suggested it could…
Read profile →Epithalon
Epithalon, also spelled Epitalon or Epithalone, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). It is most often discussed in longevity communities because of its association with pineal…
Read profile →FOXO4 and FOXO4-DRI
FOXO4-DRI is a senolytic peptide concept designed to interfere with survival signaling in senescent cells. The goal is selective removal of damaged cells that resist apoptosis, not general stimulation. Evidence lens…
Read profile →GHK-Cu
GHK-Cu is a copper-binding tripeptide most defensibly discussed for topical/local skin and scalp signaling. Evidence lens: topical/cosmetic and local skin biology are not the same as systemic anti-aging, chronic wound…
Read profile →GHRP-6 & GHRP-2
GHRP-2 and GHRP-6 are ghrelin-receptor agonists that stimulate growth-hormone release. They can also affect hunger, prolactin, cortisol, glucose, and water retention. Evidence lens: The endocrine mechanism is real, but…
Read profile →Glutathione
Glutathione is a tripeptide antioxidant made from glutamate, cysteine, and glycine. It supports redox balance, detoxification, and cellular defense. Evidence lens: Evidence differs by route and biomarker. IV glutathione…
Read profile →HCG
hCG is an LH-like hormone used medically in fertility and endocrine care. In men, it can stimulate Leydig cells to produce testosterone; In women, it can trigger ovulation in supervised protocols. Evidence lens: Unlike…
Read profile →Hexarelin
Hexarelin, also called examorelin, is a synthetic GH secretagogue in the GHRP family. It is known for strong GH release and potential cardiovascular research interest. Evidence lens: The mechanism is stronger than the…
Read profile →HGH Fragment 176-191
HGH Fragment 176-191 is a short C-terminal portion of the growth hormone molecule promoted for fat metabolism. It is not full growth hormone and should not be treated as the same product as AOD-9604. Evidence lens: Many…
Read profile →hMG
hMG contains gonadotropin activity, mainly FSH with LH activity depending on preparation. It is used in reproductive medicine to stimulate ovarian follicles or support spermatogenesis in selected endocrine contexts.…
Read profile →Humanin
Humanin is a small peptide made from a short open reading frame inside the mitochondrial 16S rRNA region. It is best understood as a cellular stress-response and survival signal, not as an approved anti-aging injection.…
Read profile →IGF-1 LR3
IGF-1 LR3 is a modified insulin-like growth factor designed to last longer and bind IGF-binding proteins differently than native IGF-1. It is discussed for muscle growth and recovery, but the biology also overlaps with…
Read profile →Ipamorelin
Ipamorelin is a ghrelin-receptor agonist used to stimulate GH release with less cortisol and prolactin spillover than older GHRPs. Evidence lens: It is cleaner than GHRP-2/GHRP-6 pharmacologically, but not FDA-approved…
Read profile →KPV
KPV is the C-terminal tripeptide of alpha-MSH and is discussed for anti-inflammatory effects, especially in gut and skin contexts. Evidence lens: Interesting mechanisms do not prove that ordinary capsules, topicals…
Read profile →Melanotan I
Melanotan I is the older research name for afamelanotide, the active drug in SCENESSE. Unlike Melanotan II, it has an FDA-approved prescription form: a 16 mg controlled-release implant for adults with erythropoietic…
Read profile →Melanotan II
Melanotan II is a melanocortin agonist best known for tanning and sexual arousal effects. Because it is nonselective, it can affect pigmentation, appetite, nausea pathways, sexual function, and cardiovascular/autonomic…
Read profile →MOTS-c
MOTS-c is a 16-amino-acid mitochondrial-derived peptide. It is discussed as an “exercise mimetic” or metabolic-signaling peptide because it is linked to skeletal-muscle metabolism, AMPK-related pathways, insulin…
Read profile →NAD+
NAD+ is a coenzyme involved in energy metabolism, sirtuin activity, DNA repair, and cellular stress responses. It appears in peptide-clinic settings because it is often injected or infused, not because it is chemically a…
Read profile →Pinealon
Pinealon is a short EDR tripeptide discussed for neuroprotection, cognitive aging, and bioregulator concepts. Evidence lens: Most support is preclinical, small, regional, or mechanistic. The guide should not present it…
Read profile →Retatrutide
Retatrutide activates GLP-1, GIP, and glucagon receptors. The glucagon component is the key differentiator from tirzepatide and may contribute to greater energy-expenditure and liver-fat effects, but it may also change…
Read profile →Selank
Selank is a synthetic analog related to tuftsin and is discussed for anxiety, stress resilience, and cognition. It is commonly used intranasally in community settings. Evidence lens: There is regional clinical use and…
Read profile →Semaglutide
Semaglutide is a GLP-1 receptor agonist with approved uses in diabetes, obesity/weight management, and cardiovascular-risk contexts depending on product and label. It is not a research peptide in the same sense as…
Read profile →Semax
Semax is an ACTH 4-10 analog designed to keep neuroactive properties without broad endocrine ACTH effects. It is used intranasally in Russian medical practice for neurologic and cognitive indications. Evidence lens: The…
Read profile →Sermorelin
Sermorelin is the first 29 amino acids of growth-hormone-releasing hormone. It stimulates the pituitary to release growth hormone, so it requires a responsive pituitary rather than bypassing the axis like direct hGH.…
Read profile →SS-31
SS-31, now approved as elamipretide under the FORZINITY label, targets cardiolipin in the inner mitochondrial membrane. The approved use is narrow. Evidence lens: Approval scope matters. Evidence supporting accelerated…
Read profile →TB-500
TB-500 is commonly marketed as a tissue-repair peptide related to thymosin beta-4, but the name is not precise. In FDA compounding safety-risk language, TB-500 refers to the thymosin beta-4 fragment LKKTETQ. Full-length…
Read profile →Tesamorelin
Tesamorelin is an approved GHRH analog used to reduce excess visceral abdominal fat in adults with HIV-associated lipodystrophy. It is not simply a generic belly-fat peptide for everyone. Evidence lens: The approved…
Read profile →Thymosin Alpha-1
Thymosin alpha-1 is an immune-modulating peptide used in some countries as thymalfasin. It is discussed for antiviral, sepsis, vaccine-response, and immune-support contexts. Evidence lens: Evidence is strongest in…
Read profile →Tirzepatide
Tirzepatide is a dual GIP and GLP-1 receptor agonist approved for type 2 diabetes and chronic weight management, with additional label expansion depending on current product status. It is a prescription drug, not a…
Read profile →Vilon
Vilon is a two-amino-acid peptide: lysine plus glutamic acid, abbreviated Lys-Glu or KE. It is usually marketed as a thymus/immune-aging bioregulator. It is not the same as thymosin alpha-1, thymalin, thymogen, or…
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